Mood, Migraine and Serotonin

The epidemiological association between migraine and mood disorders has been reported since mid-twentieth century. This monograph describes one of the first studies into migraine's association with bipolar disorder. Unlike other studies, this one looks beyond the superficial and attempts to understand the biological basis of the bipolar disorder, migraine co- morbidity. To achieve this aim, the role of central serotonergic system was investigated by carrying out neuropharmacological challenge studies in patients with bipolar disorder or migraine alone, in those who had both, and in healthy controls.