Studies on Disulphide Containing Oligodeoxynucleotides

The present book, deals with Studies on Disulphide Containing Oligodeoxynucleotides , is divided into eight chapters. The scope of the work is given in general introduction chapter-1. Detail of resume of literature is given in chapter-II. Applications of nucleic acids in drug development , and studies on disulphide bond containing oligonucleotides are explained in detail. The material used , synthesis of oligonucleotides and physico-chemical techniques / methods used are given in chapter -III. In chapters -IV modulation of oligonucleotide duplex stability via disulphide bond is described. Chapter - V revels the results of DNA/DNA duplex formation studies using disulphide bond. In chapters -VI and VII studies of Triplex DNA structure (CT motif and GT motif) formation using oligodeoxynucleotide containing disulphide bond are described. Chapter-VIII describes the results of stabilization of RNA/DNA Duplex Structure by Disulphide Bond Containing Oligodeoxynucleotide. Summary at the end high light the results obtained.