Stability and Characterization of Protein and Peptide Drugs

Stability and Characterization of Protein and Peptide Drugs

AngličtinaPevná vazbaTisk na objednávku
Springer Science+Business Media
EAN: 9780306443657
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Podrobné informace

This volume attemptsto provide the formulation scientist with casehistories involving the use of therapeutic proteins and peptides that have been mar- keted or are under clinical testing. In previous volumes of this series,funda- mental theories and principles ofprotein characterization and stability were presented in depth by researchers in their fieldsofexpertise. The way from theory to practice isnot alwaysobvious and straightforward. There isa need for practical examples of how the principles and theories are put into use, specificallyin the development of a pharmaceutical product. It is our hope that this volume will fulfillsuch a need. Itisnot asimple task to choose a panel ofproteinsand peptides from the over 200 agents in human clinical trials. We have tried to collect a wide representation of molecules of different sizes-from 10 amino acids (Leu- prolide) to 1020 amino acids (Muromonab CD3). The examples include agents derived from various sources including monoclonal antibodies (Mur- omonab CD3), recombinant DNA (human and bovine growth hormones), natural source (fibrolase), and chemical synthesis (Leuprolide). Clearly this list is not intended to be encyclopedic. It isthe first time a collection of this sort has been made accessibleto the formulation scientists involved in devel- oping protein and peptide products. Although each chapter in this volume focuses primarily on the charac- terization and stability of a specific molecule, each has unique aspects.
EAN 9780306443657
ISBN 0306443651
Typ produktu Pevná vazba
Vydavatel Springer Science+Business Media
Datum vydání 31. května 1993
Stránky 353
Jazyk English
Rozměry 234 x 156
Země United States
Sekce Professional & Scholarly
Ilustrace XXII, 353 p.
Editoři Pearlman Rodney; Wang Y. John
Edice 1993 ed.
Série Pharmaceutical Biotechnology