Stimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve Injury

Skouras, Emmanouil; Springer, Berlin;
Stimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve Injury

Stimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve Injury

Skouras, Emmanouil; Springer, Berlin;
Na objednávku
Předpokládané dodání v pátek, 22. ledna 2021
3.159 Kč s DPH
Ušetříte 351 Kč 3.510 Kč (-10%)
Přidat do košíku
Recovery of mimic function after facial nerve transection is poor: the successful regrowth of axotomized motoneurons to their targets is compromised by (i) poor axonal navigation and excessive collateral branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to facial motoneurons. As a result, axotomized motoneurons get hyperexcitable and unable to discharge. Since improvement of growth cone navigation and reduction of the ephaptic cross-talk between axons turn out be very difficult, the authorsa concentrated on the third detrimental component and proposed that an intensification of the trigeminal input to axotomized electrophysiologically silent facial motoneurons might improve specificity of reinnervation. To test the hypothesis they compared behavioral, electrophysiological and morphological parameters after single reconstructive surgery on the facial nerve with those obtained after identical facial nerve surgery, but combined with direct or indirect stimulation of the ipsilateral infraorbital (ION) nerve. The authors found that in all cases trigeminal stimulation was beneficial for the outcome by improving the quality of target reinnervation and recovery of vibrissal motor performance. Its is commonly known that the recovery of mimic functions after facial nerve injury is poor: a successful regrowth of the lesioned axons to their muscle targets is compromised by (i) poor navigation of the growth cones and excessive collateral axonal branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to the facial neuronal cell bodies in the brainstem. As a result, axotomized motoneurons become hyperexcitable and unable to discharge. Since the improvement of growth cone navigation and the reduction of the ephaptic cross-talk between axons both turn out be impossible at present, the authors focused their efforts on the third detrimental component and proposed that an intensification of the trigeminal input to the axotomized and electrophysiologically silent facial motoneurons might improve the specificity of reinnervation. To test their hypothesis, they compared behavioral, electrophysiological and morphological parameters after single reconstructive surgery on the facial nerve (or its buccal branch) with those obtained after identical facial nerve surgery but combined with indirect (removal of the contralateral infraorbital nerve, ION) or direct (massage of the mimic muscles) stimulation of the ipsilateral ION. They found that in all cases any trigeminal stimulation was beneficial for the outcome by improving both the quality of target reinnervation (reduced polyinnervation of the motor endplates) and the recovery of vibrissal motor performance (as judged by video-based motion analysis). Based on these results, the authors conclude that trigeminal stimulation is a non-invasive procedure with immediate potential for clinical rehabilitation following facial nerve reconstruction.
EAN
9783642333101
ISBN
3642333109
Typ produktu
Paperback / softback
Vydavatel
Springer, Berlin
Stránky
110
Jazyk
Angličtina
Rozměry
236 x 170 x 9
Sekce
Professional & Scholarly
Autoři
Angelov, Doychin N.; Bendella, Habib; Pavlov, Stoyan; Skouras, Emmanouil
Ilustrace
13 Tabellen
Série
Advances in Anatomy, Embryology and Cell Biology
PRODUCT UPDATE
Související produkty
14 282 084
knih
2 829 835
e-knih
Knižních titulů v nabídce
Osobní odběr zdarma na 10 místech po celé České republice
Největší knižní nabídka na českém internetu
Dárkové balení knih zdarma
Knihy z celého světa

Akceptujeme

PayPal Visa Visa Electron Maestro Mastercard
Tento web používá k poskytování služeb, personalizaci reklam a analýze návštěvnosti soubory cookies. Používáním tohoto webu s tím souhlasíte. Více informací
Rozumím